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An investigation of local high spatial resolution adaptive PET system

Liu Jingjing,Xie Qingguo

Strategic Study of CAE 2011, Volume 13, Issue 10,   Pages 105-112

Abstract:

A critical challenge in positron emission tomography (PET) is to developWe imagine a PET system, for imaging a region of interest (ROI) with ultra high performances and otherregions with normal performances by use of inhomogeneous performances PET detectors.We propose such a prototype, consisting of a few ultra high intrinsic spatial resolution PET detectors

Keywords： positron emission tomography     adaptive PET system     region of interest     local spatial resolution     inhomogeneousperformance PET detector    

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Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering Article

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Engineering 2018, Volume 4, Issue 6,   Pages 888-893 doi: 10.1016/j.eng.2018.09.007

Abstract: PETase) from Ideonella sakaiensis exhibits a strong ability to degrade poly(ethylene terephthalate) (PETTherefore, we explored the interaction between PETase and the substrate (a dimer of the PET monomer ethyleneterephthalate, 2PET), using a model of PETase and its substrate.The I179F mutant showed the highest activity, with the degradation rate of a PET film reaching 22.5 mg

Keywords： Polyesterase     PET degradation     Cell-free protein synthesis     Polyester     PETase    

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F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 913-921 doi: 10.1007/s11684-021-0874-1

Abstract: Epileptogenic hypothalamic hamartoma is characterized by intractable gelastic seizures. A systematic analysis of the overall brain metabolic pattern in patients with hypothalamic hamartoma (HH) could facilitate the understanding of the epileptic brain network and the associated brain damage effects of HH. In this study, we retrospectively evaluated 27 patients with epileptogenic HH (8 female patients; age, 2–33 years) by using 18F-fluorodeoxyglucose-positron emission tomography. The correlations among tomography result, seizure type, sex, and structural magnetic resonance imaging were assessed. Whole metabolic patterns and voxel-based morphometry findings were assessed by group analysis with healthy controls. Assessment of the whole metabolic pattern in patients with HH revealed several regional metabolic reductions in the cerebrum and an overall metabolic reduction in the cerebellum. In addition, areas showing hypometabolism in the neocortex were more widely distributed ipsilaterally than contralaterally to the HH. Reductions in glucose metabolism and gray matter volume in the neocortex were predominant ipsilateral to the HH. In conclusion, the glucose hypometabolism pattern in patients with epileptogenic HH involved the neocortex, subcortical regions, and cerebellum. The characteristics of glucose hypometabolism differed across seizure type and sex. Reductions in glucose metabolism and structural changes may be based on different mechanisms, but both are likely to occur ipsilateral to the HH in the neocortex. We hypothesized that the dentato-rubro-thalamic tract and cerebro-ponto-cerebellar tract, which are responsible for intercommunication between the cerebral cortex, subcortical regions, and cerebellar regions, may be involved in a pathway related to seizure propagation, particularly gelastic seizures, in patients with HH.

Keywords： hypothalamic hamartoma     gelastic seizure     fluorodeoxyglucose-positron emission tomography     voxel-based morphometry    

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4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomalcellular imaging agents: The effect of substituent patterns on PET directional quenching

Miguel Martínez-Calvo, Sandra A. Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 61-75 doi: 10.1007/s11705-019-1862-8

Abstract: highly pH dependent, the emission being ‘switched on’ in acidic media, while being quenched due to PETNevertheless, at higher pH, PET quenching was also found to occur from the polyamine site.is better described as a receptor -spacer -fluorophore-spacer -receptor system, where the dominant PETprocess is due to (normally less favourable) ‘directional’ PET quenching from the 4-amino-aniline unit

Keywords： sensors     pH     photoinduced electron transfer     cellular imaging     confocal microscopy    

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Solubility of CO in solid-state PET measured by pressure-decay method

CHEN Miaocan, ZHAO Ling, LIU Tao, WU Jiangwei, YUAN Weikang

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 214-219 doi: 10.1007/s11705-008-0040-1

Abstract: The solubility of CO in solid-state PET was measured using a pressure-decay method.In order to calculate the solubility of CO in the amorphous region of PET, the crystallinity of solidstate PET dissolved in CO at different pressures and temperatures was measured by differential scanningThe solubility of CO in the amorphous region of PET at 373.15 K, 398.15 K and 423.15 K was correlated

Keywords： Sanchez-Lacombe equation     solid-state PET     different     relationship     calorimetry    

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Laser sintering of Cu nanoparticles on PET polymer substrate for printed electronics at different wavelengths

Juan Carlos HERNANDEZ-CASTANEDA, Boon Keng LOK, Hongyu ZHENG

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 2,   Pages 303-318 doi: 10.1007/s11465-019-0562-x

Abstract: This study explores the feasibility of different laser systems to sinter screen-printed lines from nonconductive copper nanoparticles (Cu NPs) on polyethylene terephthalate polymer film. These materials are commonly used in manufacturing functional printed electronics for large-area applications. Here, optical and thermal characterization of the materials is conducted to identify suitable laser sources and process conditions. Direct diode (808 nm), Nd:YAG (1064 nm and second harmonic of 532 nm), and ytterbium fiber (1070 nm) lasers are explored. Optimal parameters for sintering the Cu NPs are identified for each laser system, which targets low resistivity and high processing speed. Finally, the quality of the sintered tracks is quantified, and the laser sintering mechanisms observed under different wavelengths are analyzed. Practical considerations are discussed to improve the laser sintering process of Cu NPs.

Keywords： laser sintering     copper nanoparticles     printed electronics    

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Tetra-detector size exclusion chromatography characterization of molecular and solution properties of

Qingbin Guo,Sheng Chang

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0922-x

Abstract: Tetra-detector HPSEC was evaluated for the SMP characterization Molecular weight and intrinsic viscosityBased on the tetra-detector HPSEC determined absolute molecular weights and intrinsic viscosity, a universalTwo factors which can be derived from the tetra-detector HPSEC analysis were proposed for the characterizationpolarization layers formed in membrane filtration based on the molecular properties determined by the tetra-detector

Keywords： Soluble microbial product     Extracellular polymeric substance     Membrane bioreactor     Membrane fouling     Molecular weight     Intrinsic viscosity    

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Erratum to: On secondary new particle formation in China

Markku KULMAMA,Tuukka Petäjä,Veli-Matti KERMINEN,Joni KUJANSUU,Taina RUUSKANEN,Aijun DING,Wei NIE,Min

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0857-7

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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 440-444 doi: 10.1007/s11684-017-0523-x

Abstract: and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET

Keywords： Philadelphia chromosome     acute myeloid leukemia     mass     osteolysis     positron emission tomography    

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Icing tunnel experimental study of the static pressure detector

Peng Youxin,Zheng Li,Lin Guiping

Strategic Study of CAE 2009, Volume 11, Issue 11,   Pages 51-55

Abstract: style="text-align: justify;">This work presented experimental approach of studying static pressure detectorThe main topics are: the experimental items of the detector in the icing tunnel, the experimental conditionsAccording to the features of the icing tunnel, the experimental results of the detector and some suggestion

Keywords： static pressure detector     icing tunnel experiment     anti-ice    

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The relevance of James Lovelock’s research and philosophy to environmental science and academia

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1639-7

Abstract: Lovelock is also remembered as the co-inventor of the electron capture detector that eventually allowed

Keywords： Academic independence     Climate change     Electron capture detector     Environmental equilibrium     Global warming    

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PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

Xiao He, Chentao Jin, Mindi Ma, Rui Zhou, Shuang Wu, Haoying Huang, Yuting Li, Qiaozhen Chen, Mingrong Zhang, Hong Zhang, Mei Tian

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 602-609 doi: 10.1007/s11684-019-0704-x

Abstract: stimulation to the dPAG was performed to induce panic-like behaviors, and positron emission tomography (PETCompared with the baseline, post-optogenetic stimulation PET imaging demonstrated that the glucose metabolismTaken together, these data indicated that PET imaging can successfully detect downstream neurofunctional

Keywords： panic disorder (PD)     positron emission tomography (PET)     optogenetics     dorsal periaqueductal gray (dPAG)    

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Influence of recycled polyethylene terephthalate fibres on plastic shrinkage and mechanical properties of concrete

Necat ÖZAŞIK; Özgür EREN

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 6,   Pages 792-802 doi: 10.1007/s11709-022-0849-6

Abstract: Polyethylene terephthalate bottles production has drastically increased year after year due to high versatility of polyethylene terephthalate plastics and considerable consumption of beverages. In tandem with that increase, the major concern of society has been the improper disposal of this non-biodegradable material to the environment. To deal with this concern, recycled polyethylene terephthalate bottles were incorporated in concrete as fibre reinforcements in this study. The objective of this research is to evaluate the mechanical properties of recycled polyethylene terephthalate fibre reinforced concrete (RPFRC) in comparison with control concrete without fibres. polyethylene terephthalate fibres with three different diameters (0.45, 0.65, and 1.0 mm) and two lengths (20 and 30 mm) were added at various proportions (0.5%, 1.0%, 1.5% and 2.0%) by volume of concrete in order to determine the effect of fibres initially on compressive, flexural and splitting tensile strengths of concrete. The results revealed that none of the fibres have detrimental effects up to 1% volume fraction, however further addition caused slight reductions on mechanical properties in some conditions. Plastic shrinkage resistance and impact resistance tests were also performed according to related standards. Polyethylene terephthalate fibres were observed to have marked improvements on those properties. Such a good performance could be attributed primarily to the bridging effect of fibres.

Keywords： recycled PET     fibre-reinforced concrete     mechanical properties     plastic shrinkage     impact energy    

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Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: The local microenvironment is essential to stem cell-based therapy for ischemic stroke, and spatiotemporal changes of the microenvironment in the pathological process provide vital clues for understanding the therapeutic mechanisms. However, relevant studies on microenvironmental changes were mainly confined in the acute phase of stroke, and long-term changes remain unclear. This study aimed to investigate the microenvironmental changes in the subacute and chronic phases of ischemic stroke after stem cell transplantation. Herein, induced pluripotent stem cells (iPSCs) and neural stem cells (NSCs) were transplanted into the ischemic brain established by middle cerebral artery occlusion surgery. Positron emission tomography imaging and neurological tests were applied to evaluate the metabolic and neurofunctional alterations of rats transplanted with stem cells. Quantitative proteomics was employed to investigate the protein expression profiles in iPSCs-transplanted brain in the subacute and chronic phases of stroke. Compared with NSCs-transplanted rats, significantly increased glucose metabolism and neurofunctional scores were observed in iPSCs-transplanted rats. Subsequent proteomic data of iPSCs-transplanted rats identified a total of 39 differentially expressed proteins in the subacute and chronic phases, which are involved in various ischemic stroke-related biological processes, including neuronal survival, axonal remodeling, antioxidative stress, and mitochondrial function restoration. Taken together, our study indicated that iPSCs have a positive therapeutic effect in ischemic stroke and emphasized the wide-ranging microenvironmental changes in the subacute and chronic phases.

Keywords： ischemic stroke     microenvironment     induced pluripotent stem cells (iPSCs)     positron emission tomography (PET    

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On secondary new particle formation in China

Markku Kulmala,Tuukka Petäjä,Veli-Matti Kerminen,Joni Kujansuu,Taina Ruuskanen,Aijun Ding,Wei Nie,Min

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 5, doi: 10.1007/s11783-016-0850-1

Abstract: Formation of new atmospheric aerosol particles is a global phenomenon that has been observed to take place in even heavily-polluted environments. In China, new particle production has been observed at very high pollution levels (condensation sink about 0.1s ) in several megacities. A holistic scientific understanding on the atmospheric phenomena associated with air quality as a whole, as well as on the connection between air quality and climate, is lacking at the moment.With a network of observation stations, we will be able to understand the interactions and feedbacks associated with the urban pollution mixture, and ultimately, are ready to make targeted strategies for the pollution control. This paper summaries the recent advances in studying secondary new aerosol formation in China and shows how increased process-level understanding will help us to understand air quality-climate-weather interactions and how the feedbacks and interactions affect the air quality in highly-polluted environments such as those frequently encountered in Chinese megacities. Formation of new atmospheric aerosol particles is a global phenomenon that has been observed to take place in even heavily-polluted environments. However, in all environments there appears to be a threshold value of the condensation sink (due to pre-existing aerosol particles) after which the formation rate of 3 nm particles is no longer detected. In China, new particle production has been observed at very high pollution levels (condensation sink about 0.1 s ) in several megacities, including Beijing, Shanghai and Nanjing as well as in Pearl River Delta (PRD). Here we summarize the recent findings obtained from these studies and discuss the various implications these findings will have on future research and policy.

Keywords： Aerosol particles     Heavily-polluted environments     Condensation sink     New particle production     Megacities    

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Title Author Date Type Operation

An investigation of local high spatial resolution adaptive PET system

Liu Jingjing,Xie Qingguo

Journal Article

Enhanced Poly(ethylene terephthalate) Hydrolase Activity by Protein Engineering

Yuan Ma, Mingdong Yao, Bingzhi Li, Mingzhu Ding, Bo He, Si Chen, Xiao Zhou, Yingjin Yuan

Journal Article

F-FDG-PET glucose hypometabolism pattern in patients with epileptogenic hypothalamic hamartoma

Journal Article

4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomalcellular imaging agents: The effect of substituent patterns on PET directional quenching

Miguel Martínez-Calvo, Sandra A. Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson

Journal Article

Solubility of CO in solid-state PET measured by pressure-decay method

CHEN Miaocan, ZHAO Ling, LIU Tao, WU Jiangwei, YUAN Weikang

Journal Article

Laser sintering of Cu nanoparticles on PET polymer substrate for printed electronics at different wavelengths

Juan Carlos HERNANDEZ-CASTANEDA, Boon Keng LOK, Hongyu ZHENG

Journal Article

Tetra-detector size exclusion chromatography characterization of molecular and solution properties of

Qingbin Guo,Sheng Chang

Journal Article

Erratum to: On secondary new particle formation in China

Markku KULMAMA,Tuukka Petäjä,Veli-Matti KERMINEN,Joni KUJANSUU,Taina RUUSKANEN,Aijun DING,Wei NIE,Min

Journal Article

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Journal Article

Icing tunnel experimental study of the static pressure detector

Peng Youxin,Zheng Li,Lin Guiping

Journal Article

The relevance of James Lovelock’s research and philosophy to environmental science and academia

Journal Article

PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder

Xiao He, Chentao Jin, Mindi Ma, Rui Zhou, Shuang Wu, Haoying Huang, Yuting Li, Qiaozhen Chen, Mingrong Zhang, Hong Zhang, Mei Tian

Journal Article

Influence of recycled polyethylene terephthalate fibres on plastic shrinkage and mechanical properties of concrete

Necat ÖZAŞIK; Özgür EREN

Journal Article

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke

Journal Article

On secondary new particle formation in China

Markku Kulmala,Tuukka Petäjä,Veli-Matti Kerminen,Joni Kujansuu,Taina Ruuskanen,Aijun Ding,Wei Nie,Min

Journal Article